|
KMID : 0043319890120010017
|
|
Archives of Pharmacal Research
1989 Volume.12 No. 1 p.17 ~ p.21
|
|
|
Reactivity of 7-Dithiocarboxy-imidazo[2,1-b]thiazolium-betaine with Aliphatic Alkylating Agents
|
|
Song JW
Suh ME/Yoo KH/Park SW
|
|
|
Abstract
|
|
|
|
We have reported earlier on the reactivity of 7-dithiocarboxy-3-phenyl-5,6-dihydro imidazo [2,1-b]thiazolium-betaine with several para-substituted phenacyl bromides. In this work reactions of 7-dithiocarboxy-3-phenyl(or methyl)-5,6-dihydro imidazo[2,1-b]thiazolium-betaine with a series of aliphatic alkylating agents of alpha-halo ketone, gamma-halo keto ester and alpha-halo ester were examined for the similar purpose. In case of alpha-halo ketone or gamma-halo keto ester such as alpha-chloro acetone or ethyl 4-chloro acetoacetate new biheterocyclic compound was obtained via ring transformation reaction. However, reaction of the betaine with methyl(or ethyl) bromoacetate used as alpha-halo ester, gave, instead, S-alkylated quarternary ammonium salt.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|